Division of Plant Pathology and Microbiology in Plant Sciences Department
Research project:

The molecular regulation of phenazine antibiotic biosynthesis in Pseudomonas aureofaciens


This free-living root-associated bacterium can colonize wheat and barley roots and protect the plants from Gaeumannomyces graminis var. tritici , the causative agent of take-all disease through its production of phenazine antibiotics. This research has shown that phenazine production is regulated by a complex interconnected sensory system including N -acyl homoserine lactone (AHL)-mediated quorum sensing involving PhzR and PhzI. In addition, the GacS/GacA two component regulatory system and the RpeA negative two component regulatory systems influence phenazine gene expression. Phenazine production is also regulated at the post-transcriptional level.

   
For more information: Dr. Sandy Pierson, lsp@u.arizona.edu
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