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CALS researcher focuses on maternal epigenetic and nutrition links to breast cancer
University of Arizona Cancer Center member Donato Romagnolo, PhD, MSc, is leading a study that suggests that external environmental and dietary factors in pregnant women may have an impact on future breast cancer risk for the offspring.
More than 40,000 Americans die from breast cancer each year. However, fewer than 10 percent of those cases involve a patient with a hereditary link through mutations in the BRCA-1 gene. Dr. Romagnolo and his team have looked into what other factors and mechanisms may contribute toward abnormal BRCA-1 behavior.
“We wanted to figure out what could possibly be responsible for the large percentage of breast cancer cases where patients have no family history of the disease, but have lower or no detectable BRCA-1,” Dr. Romagnolo said.
His team’s research suggests that various environmental and dietary conditions during pregnancy can activate the aromatic hydrocarbon receptor (AhR), which functions as a cellular sensor, leading to impaired mammary gland development in the womb. This event can, eventually, increase the offspring’s susceptibility for breast cancer — particularly if exposure to these external factors happens during key gestational development periods.
An important implication of these observations is that irregular AhR behavior during pregnancy may increase the risk of breast cancer in offspring and future generations, even for individuals with no familial history of the disease or BRCA-1 mutation carriers. The biological process through which these changes could take place is known by scientists as “epigenetics,” which can modify the risk of breast cancer without the need for alterations in the genetic code of BRCA-1 or other genes.
Read more from this October 29 UA Cancer Center article at the link below. Romagnolo is a professor in the Department of Nutritional Sciences.
Date released:Dec 7 2013