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Endothelializing Vascular Graft with Protein Nanoarrays
Objective: Use of protein nanoarrays on a vascular graft for successful endothelialization.
Researchers: David You, Jessica Gamboa, Katherine McCracken, Katrina DeCook, Samir Mohandes
Collaborators: Prof. Marvin Slepian (U Arizona);
Prof. Mark Riley (U Arizona)
Current funding: BIO5 Institute;
NIH Cardiovascular Training Grant (HL007955)
Past funding: NIH NIBIB (R03EB006754)
| A protein nanoarray made by size-dependent self-assembly (SDSA) (left) is installed within a continuous bioreactor to grow HUVECs on it. Saturated, monolayered, yet aligned growth is observed, through both focal adhesion and endocytosis of nanoparticles (middle and right). |
"Wire-Guide" Droplet Microfluidics for Reprogrammable and Rapid PCR
Objective: Reprogrammable and rapid PCR for on-site pathogen identification.
Researchers: Dustin Harshman, Christopher Fronczek, Scott Angus, Roberto Reyes
Current funding: QIA;
NIH Cardiovascular Training Grant (HL007955);
WAESO
| Wire-guided rapid droplet mixing (left); Wire-guided quick PCR system (middle); 30-cycle RT-PCR for 2009 H1N1 flu could be finished in 6 min 50 s for 10 uL volume such that gel imaging and gene sequencing could be done in a reproducible and reliable manner (right). |
Paper Microfluidics + Smart Phone for Water Quality and Food Safety
Objective: Low-cost smart phone detection of waterborne and foodborne pathogens.
Researchers: Tu San Park, Pei-Shih Liang, Wenyue Li
| Smart phone detects immunoagglutination from paper microfluidics (left); Benchtop apparatus used to optimize optical parameters (middle left); Sample is loaded into paper microfluidics by capillary action (middle right); Smart phone captures the image (right). |
Last revised: April 18, 2012.