Past funding: APQA; WSP; Tech Launch Arizona; BIO5 Institute; Desert Tech; WAESO (NSF); NVRQS; NIH; NSF; Arizona Department of Commerce; BMD; University of Arizona
Objective: Paper microfluidics for medical diagnostics.
Researchers: Tu San Park, Christopher Fronczek, Cayla Baynes, Soohee Cho, Tigran Nahapetian, Serge Dogbevi
|1. Smartphone attachment for quantifying the band intensities from lateral flow assays.
2. Smartphone-based fluorescence microscope.
3. Paper microfluidics for quantifying bacteria.
4-5. Smartphone application for quantifying the optical signals from paper microfluidics.
Objective: Lab-on-a-chip or light-scatter biosensing for air quality.
Researchers: Dustin Harshman, Cayla Baynes, Katherine McCracken, Brianna Rao
|1. Lab-on-a-chip is attached to a smartphone for optical detection.
2. Monitoring H1N1 flu from a mock-up human environment with lab-on-a-chip.
3. CFD simulation for aerosol transport within animal housing.
4. Mie scatter simulation for microbeads and dust particles.
|Tissue Engineering and Organ-on-a-Chip
Objective: Use of nanostructured surfaces for tissue engineering and organ-on-a-chip applications.
Researchers: Ariana Nicolini, Soohee Cho, Kirstie Birmingham, Victoria Raught
Collaborators: Prof. Terrence Monks (U Arizona); Prof. Marvin Slepian (U Arizona)
|1. Nanostructured ensemble surface, created by e-beam nanolithography and size-dependent self-assembly.
2. Flow-resistant adhesion and proliferation of HUVECs on nanostructured surface.
3 & 4. Linear alignment of fibroblast on sinosoidal wave pattern, towards cellular irrigation.|
|Food Safety and Water Quality
Objective: Lab-on-a-chip for food safety and water quality.
Researchers: Christopher Fronczek, Tu San Park, Scott Angus, Katherine McCracken
Collaborator: Prof. Kelly Reynolds (U Arizona)
|1. Handheld lab-on-a-chip device for detecting foodborne pathogens.
2. E. coli detection from lettuce.
3. Salmonella detection from poultry packaging.
4. Wine tasting on paper microfluidics.
5. Monitoring bacterial contamination from soil with lab-on-a-chip.
|Fast PCR Diagnostics
Objective: Extremely fast (<5-min thermocycling), portable, and all-in-one PCR device for on-site pathogen identification.
Researchers: Dustin Harshman, Scott Angus, Brianna Rao
Collaborator: Dr. Jae-Young Song (APQA)
|1. Wire-guided droplet manipulator device.
2. Disposable circular cartridge heating module.
3. Wire-guided droplet manipualtions for DNA extraction.
4. Droplet PCR thermocylcing in less than 5 min (for 30 cycles).|
Last revised: July 8, 2014.