Nomenclature

Home Calpain Links Calpain Reagents Storage and Handling Nomenclature Properties of the Calpains 2001 FASEB Conference

At the 2001 FASEB Conference, The Calpain Family in Health and Disease, a discussion was held concerning calpain nomenclature. The proposed changes are summarized below. You may download a copy of these tables in pdf format. If you have comments or suggestions on the nomenclature of the calpains, please fill out our survey form.

Table 1. Mammalian calpain family

Calpain protein #

Calpain gene

Other Names

EF-hand

Tissue Type

Species

Chromo-some  #

Genebank Accession #

Calpain 1

capn1

-Calpain,

CAPN1  

+

Ubiquitous

Human

11q13

X04366

Mouse

19

NM_007600

Rat

NA

NM_019152

Calpain 2

capn2

m-Calpain,

CAPN2

+

Ubiquitous

Human

1q41

NM_001748

Mouse

NA

NM_009794

Rat

NA

NM_017116

    Calpain
3

capn3

nCL-1,

p94,

(Lp82, Lp85

Rt88)

+

Skeletal

muscle,

lens, retina

Human

15q15.1

X85030

Mouse

2

NM_007601

AF091998

Rat

NA

NM_017117

U96367

 

     Calpain 5

capn5

htra3

nCL-3

-

Ubiquitous (High in colon, small intestine and testis)

Human

11q14

NM_004055

Mouse

7

NM_007602

Rat

NA

NA

 

Calpain 6

 

capn6

CAPNX,

Calpamodulin

-

Placenta?

Human

Xq28

NM_014289

Mouse

X

NM_007603

Rat

NA

AF067793

Calpain 7

capn7

palBH

-

Ubiquitous

Human

3p24-p25

AB028639

Mouse

NA

NM_009796

Rat

NA

NA

Calpain 8

 

capn8

 

nCL-2

+

Stomach mucosa

Human

Mouse

Rat

1q41

NA

NA

AA_043093^

NA

D14479-D14480

 

Calpain 9

capn9

nCL-4

+

Digestive track

Human

1q42

NM_006615

Mouse

NA

U89513

Rat

NA

U89514

Calpain 10

capn10

CAPN10,

CaPn8

-

Ubiquitous

Human

2q37.3

AF089088,

AF089090 -96

Mouse

NA

NM_011796

AF089089

Rat

NA

AF227909

Calpain 11

capn11

 CAPN11

+

Testis

Human

6p12

AJ242832

Mouse

NA

NA

Rat

NA

NA

Calpain 12

capn12

CAPN12

+

Ubiquitous

(High in hair follicle)

Human

NA

NA

Mouse

19q13

AJ289241

Rat

NA

NA

Calpain 13

capn13

CAPN13

+

Testis/Lung

Human

2p22.2-p22.3

(AC068689) ^

Calpain 14

capn14

  CAPN14

_

Ubiquitous

Human

2p22.2-p22.3

(AC015980) ^

Calpain 15

capn15

Sol H  

-

Ubiquitous

Human

16p13.3

U85647

Mouse

17A3.3

NM015830

Rat

NA

NA

Calpain Small Subunit 1

capn-s1 or

cpns1

CAPN4

+

Ubiquitous

Human

19q13.1

NM_001749

Mouse

NA

NM_009795

Rat

NA

RNU10861

Calpain Small Subunit 2

capn-s2 or

cpns2

 

+

NA

Human

16

AC026802

Mouse

NA

AK009171

Rat

NA

NA

*Proposed name
# Old name
^ Partial sequences only
NA = Not available
Note: There will be no calpain 4

-Calpain =protein heterodimer of Calpain 1 and one small subunit

m-Calpain =protein heterodimer of Calpain 2 protein and one small subunit

 

Table 2. Calpain family in Drosophila

Drosophila Calpain protein

gene

Other names

Calpain A

CalpA

Dm-Calpain A

Calpain B

CalpB

Dm-Calpain B

Calpain C

CalpC

CCG3692

Calpain D

CalpD

SOL

 

Table 3.Nematode C. elegans calpain


There are 12 putative calpains with 7 identified in C. elegans.

C. elegans Calpain protein

gene

Other names

Calpain 1

capn1

CE00518/ p71

Calpain 2

capn2

CE01070/ p92

Calpain 3

capn3

CE24374/ p72.8

Calpain 4

capn4

CE25258/ p76

Calpain 5

capn5

CE16260/ TRA-3

Calpain 6

capn6

CE25611/ p90

Calpain 7

capn7

CE25612/ p86

 

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